🏈 Two Showdowns. Two Road Favorites. One Loss Among Four Teams.

Saturday's college football schedule features two heavyweight matchups involving four teams with a combined one loss. And in both games, the home team is the underdog.

Ohio State (-3) at Indiana — Noon ET, Fox
Notre Dame (-10.5) at BYU — 7:30 p.m. ET, ABC

For Wes Reynolds, a proud Indiana graduate, the first game is personal.

He calls Ohio State–Indiana "arguably the biggest and certainly the most anticipated game in the history of Memorial Stadium."

But the Hoosiers aren't getting much respect.

"Most of the national media discussion and punditry predict an Ohio State win and say this is where Indiana gets its comeuppance," Wes writes.

Wes makes the case for Indiana — and has 10 other plays on his Saturday card.

>> Wes Reynolds' Week 7 College Football Best Bets

Meanwhile, Matt Youmans has had a strong opinion on Ohio State–Indiana all week. He also sees a potentially decisive factor in the night's other marquee matchup.

BYU running back LJ Martin, one of the nation's best, is sidelined. That leaves quarterback Bear Bachmeier facing a Notre Dame defense allowing just 11 points per game.

As Matt puts it, Bachmeier may have to become a "one-man wrecking crew."

Matt has picks on both marquee games, plus two more.

>> Matt Youmans' Week 7 Best Bets

And Dave "Dog or Pass" Tuley has weighed in on both games as well.

>> Tuley's Takes: Four College Football Picks

Catch Wes with Matt Brown on Ready, Set, Bet tonight from 6–9 p.m. ET. Wes' mood TBD.

🎓 More Week 7 College Football Best Bets

Zach Cohen — Ohio State–Indiana Plus 2 More Plays

Adam Burke — 3 Best Bets

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🏆 How the Circa Invitational Handicapped Ohio State–Indiana

The Circa Friday Football Invitational contestants didn't shy away from Saturday's biggest game. Seven selections came in on Ohio State–Indiana, including two on the total.

Indiana +3: Jack Lenenberg, Clyde Walker

Ohio State -3: Jeff Whitelaw, Chris Macero, Paul Stone

Under 50.5: Paul Stone, Weston Stradtman

>> See All 175 Invitational Picks From 25 Handicappers

🎯 More Picks From the VSiN Community

Brad Taylor, who co-hosts Live Bet Saturday with Will Hill from our Kentucky studio (3–6 p.m. ET), has posted his plays for today's games in the VSiN Community.

>> Brad Taylor's Saturday Best Bets

🌙 The Get-Out Special

There's always one more game.

And for college football bettors, that often means a late-night trip to Hawaii.

Joe Freda has handicapped tonight's New Mexico at Hawaii matchup and posted his analysis in the VSiN Community.

>> Joe Freda's New Mexico–Hawaii Get-Out Special

🧰 Build Your Own CFB Card

📈 Makinen's Week 7 Analytics Report →

🏈 Matchups & Advanced Stats →

📊 DraftKings & Circa Betting Splits →

🎯 Every Week 7 Pick From VSiN Hosts & Guests →

⚡ Complete CFB Week 7 Betting Hub →

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🏈 Start Building Your NFL Week 6 Card

Injury news and some unusual differences between sportsbooks are adding intrigue to Sunday's NFL slate.

Bears: Caleb Williams (hamstring) is officially questionable against Atlanta, despite a full week of practice. Michael Penix Jr. will start for the Falcons.

Ravens: Lamar Jackson (ankle) has been ruled out against the Browns.

Packers: Running back Josh Jacobs is expected to come off the Commissioner Exempt List and be eligible to play in Week 7.

>> Check the Complete NFL Injury Report

📊 Two NFL Lines That Don't Agree

As Circa owner Derek Stevens pointed out to Matt Youmans on Friday, you don't often see significant differences between sportsbooks on NFL games.

But there were two notable exceptions as of Friday night:

Bears–Falcons: Pick'em at Circa; Chicago -1.5 at DraftKings.

Saints–Giants: Pick'em at Circa; New Orleans -1.5 at DraftKings.

>> DraftKings & Circa NFL Betting Splits

🎯 NFL Week 6 Best Bets

Zach Cohen — 9 Picks

Dave Tuley — Takes on Every Game

Steve Makinen — 7 Plays

Adam Burke — First Touchdown Scorer Picks

Adam Burke — Favorite NFL Player Props

👉 Matt Youmans → New NFL picks coming this morning

👉 Wes Reynolds → New NFL picks coming this morning

🧰 More NFL Tools

The BOLT picks will be posted at 1 p.m. PT today.

⚡ Today's BOLT Player Prop Trends →

🤖 Opta AI NFL Player Prop Projections →

🔎 NFL Player Prop Analyzer →

🏈 Sunday's Matchups & Advanced Stats →

🎯 Every NFL Week 6 Pick From VSiN Hosts & Guests →

⚡ Complete NFL Week 6 Betting Hub →

🎥 John Hansen's 17 Favorite Player Props

Want more player-prop ideas? John Hansen has a list of 17 favorites for the NFL slate.

>> Watch John's Player Prop Breakdown on YouTube

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⚾ ALCS Game 4, Take Two

Friday's Rays–Guardians game was washed out, and now the handicapping gets even trickier.

ALCS Game 4 has been rescheduled for tonight (8 p.m. ET), forcing both teams to adjust their pitching plans.

As Adam Burke puts it: "From a betting standpoint, this game remains a giant mess."

Pitchers who expected to work Friday are now shifting to Saturday. And the weather could limit offensive upside for two teams that weren't hitting many home runs to begin with.

Does the extra day change the betting approach? Adam has updated his Game 4 analysis.

>> Adam Burke's Updated Rays–Guardians Game 4 Preview

⚡ Quick Hits

🏒 NHL from Jonathan Davis →

⚽ EPL & European Soccer Picks →

🥊 UFC Picks →

🏇 Horse Racing Picks →

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